時間：2024-11-22(五) 15:10 pm

講題：High-Efficiency Lipid Nanoparticles: Formation Mechanism, Characterization and Applications

講者：Prof. Mu-Ping Nieh

服務單位：University of Connecticut

地點：93406

主持人：孫亞賢 教授

摘要 :

Drug delivery using lipid nanoparticles (LNPs) have evolved throughout the last few decades as there are many challenges to be overcome: in vivo stability, release mechanism, specific targeting, toxicity, feasibility for mass production, uniformity in size or size distribution, etc. Both chemical and physical endeavors have been pursued in improving the delivery platform. Our research group has developed a nanoparticulate platform – bicellar system, which shows low toxicity and high stability and cellular uptake, allows for entrapping both hydrophobic and hydrophilic species, can be easily manufactured into uniform size of < 50 nm particles and has the potential to conjugate targeting molecules for different diseases. In this presentation, I will explain the pathway how we develop and rationally design the bicellar LNPs to be a promising, high-efficiency theranostic delivering nanoparticulate system.

學經歷 :

Dr. Mu-Ping Nieh received his BS degree in Chemical Engineering from NTU and his PhD degree in Chemical Engineering/Polymer Sci & Eng from UMass Amherst. He continued research career at National Institute of Standards and Technology (NIST) and National Research Council (NRC) in Canada before he joined the University of Connecticut at Storrs in 2010. Presently, he serves as the director of the Polymer Program at the Institute of Materials Science at UCONN. His expertise is to apply light, X-ray and neutron scattering in characterizing material structures. His current research mainly focuses on controlling self-assembling morphology through molecular properties and establishing structure-function relationships through experimental design. He is a member of the Connecticut Academy of Science and Engineering (CASE) and has recently received the presidential M1 mentorship award at UCONN.