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蔡少偉 退休教師

蔡少偉 退休教師

聯絡方式：

E-mail：tsai@mail.cgu.edu.tw

學歷

  • 成功大學  化工博士（1985 ）
  • 成功大學  化工碩士（1979 ）
  • 清華大學  化工學士（1977 ）

經歷

  • 長庚大學生化與生醫工程研究所 所長 2006/08-迄今
  • 長庚大學生化與生醫工程研究所 教授 2005/08-迄今
  • 成大化學工程學系 教授 1989/08-2005/07
  • 司圖加大學熱力與熱程工程研究所 訪問教授 2004/08-2004/10
  • 成大工學院 副院長 2002/09-2004/07
  • 成大化學工程學系 系主任 1997/08-1999/07
  • 成大教務處學服組 主任 1990/08-1993/07
  • 愛荷華大學化學及生化工程學系 訪問教授 1994/02-1995/01
  • 成大化學工程學系 副教授 1985/06-1989/07
  • 麻省理工學院化學工程學系 訪問學者 1987/09-1988/06
  • 成大化學工程學系 講師 1982/08-1985/05

研究與教學獎項

  • 台灣化學工程學會99年度傑出論文獎
  • 國科會研究專題主持費（90-98學年度）
  • 國科會研究獎助費甲等獎(76-80學年度、84-89學年度)
  • 國科會研究獎助費優等獎(81-83學年度)
  • 教育部87年度有關產業實際問題優良博士論文獎（指導教授）
  • 教育部78年優良教學獎˙
  • 教育部81年優良公共服務獎

專業領域

  • 酵素工程
  • 生化工程
  • 單元操作

教師著作

期刊論文

  1. Wang, P. Y., Wu, C. H., Ciou, J. F., Wu, A. C., Tsai, S. W., 2010. “Kinetic   resolution of (R,S)-pyrazolides containing substituents in the leaving pyrazole for increased lipase enantioselectivity,” J. Mol. Cat. B: Enzymatic, 66, 113-116.
  2. Wu, A. C. Wang, P. Y. Lin, Y. S. Kao, M. F. Chen, J. R. Ciou, J. F. Tsai, S. W.   2010. “Improvements of enzyme activity and enantioselectivity in lipase-catalyzed alcoholysis of (R,S)-azolides,” J. Mol. Cat. B: Enzymatic, 62, 235-241.
  3. Wang, P. Y., Chen, Y. J., Wu, A. C., Lin, Y. S., Kao, M. F., Chen, J. R., Ciou, J. F., Tsai, S. W. 2009. “(R,S)-Azolides as novel substrates for lipase-catalyzed hydrolytic resolution in organic solvents.” Adv. Syn. Cat., 351, 2333-2341.
  4. Chen, H. M. Wang, P. Y., Tsai, S. W. 2009. “Carica papaya lipase-catalyzed transesterification resolution of secondary alcohols in organic solvents,’ JTIChE, 40, 549-554.
  5. Wang, P. Y., Tsai, S. W. 2009. “Modification of enzyme surface negative charges via covalent Immobilization for tailoring the activity and enantioselectivity,’ JTIChE, 40, 364-370.
  6. Wang, P. Y., Tsai, S. W. 2009. “Hydrolytic resolution of (R,S)-3-hydroxy-3-phenylpropionates by esterase from Klebsiella oxytoca: Effects of leaving alcohol, covalent immobilization and aqueous pH,” J. Mol. Cat. B: Enzymatic, 59, 70-75.
  7. Wang, P. Y., Tsai, S. W. 2009. “Enzymatic hydrolytic resolution of (R,S)-tropic acid esters and (R,S)-ethyl α-methoxyphenylacetate in biphasic media,” J. Mol. Cat. B: Enzymatic, 57, 158-163.
  8. Wang, P. Y., Tsai, S. W., Chen, T. L. 2008. “Improvement of enantioselectivity and stability of Klebsiella oxytoca hydrolase immobilized on Eupergit C 250L,” J. Chem. Technol. Biotechnol., 83, 1518-1525.
  9. Wang, P. Y., Tsai, S. W., Chen, T. L. 2008. “Improvements of enzyme activity and enantioselectivity via combined substrate engineering and covalent immobilization,” Biotechnol. Bioeng., 101, 460-469.
  10. Zhao J. H., Liu, H. L., Lin, H. Y., Huang, C. H., Fang, H. W., Tsai, S. W. 2007. “Semiemperical molecular orbital studies of the acylation step in the lipase-catalyzed ester hydrolysis,’ J. Ch. Chem. Soc., 54, 835-842.
  11. Wang, P. Y., Chen, T. L., Tsai, S. W. 2007. “Enzymatic hydrolytic resolution of (R,S)-α-chlorophenyl acetates in biphasic media,” J. Mol. Cat. B: Enzymatic 48, 16-22.
  12. Wang, P. Y., Chen, T. L., Tsai, S. W., K Wolfgang, K. 2007. “Hydrolytic resolution of (R,S)-2-hydroxycarboxylic acid esters in biphasic media: Implication for rate-limiting formation or breakdown of tetrahedral intermediates in acylation step,” Biotechnol. Bioeng., 98, 30-38.
  13. Cheng, Y. C., Tsai, S. W. 2007. “Carica papaya lipase: an effective biocatalyst for esterification resolution of (RS)-2-(chlorophenoxy)propionic acid,” Biochem. Eng. J. 35, 318-324.
  14. Wang, P. Y., Chen, T. L., Tsai, S. W., Cipiciani, A., Bellezza, F., Ruzziconi, R. 2006. “Enantioselective hydrolysis of methyl 2-fluoro-2-arylpropionates by lipases in water-saturated isooctane,” J. Mol. Cat. B: Enzymatic, 42, 90-94.
  15. Tsai, S. W., Chen, C. C. Yang, H. S. Ng. I. S. Chen, T. L. 2006. “Implication of substrate-assisted catalysis on improving lipase activity or enantioselectivity in organic solvents,” BBA: Protein and Proteomics, 1764, 1424-1428.
  16. Ng, I. S., Tsai, S. W. 2006. “Dynamic kinetic resolution of (R,S)-profen 2,2,2-trifluoroethyl thioesters in organic solvents via partially purified Carica papaya lipase,” ChIChE, 37, 375-382.
  17. Wen, W. Y., Ng, I. S. Tsai, S, W. 2006. “Lipase-catalyzed dynamic hydrolytic resolution of (R,S)-2,2,2-trifluoroethyl α-chlorophenyl acetate in water-saturated isooctane,” J. Chem. Technol. Biotechnol., 81, 1715-1720.
  18. Domínguez de María, P., Sinisterra, J. V., Tsai, S. W., Alcántara, A. R. 2006. “Carica papaya lipase (CPL): an emerging and versatile biocatalyst,” Biotechnol. Advances 39, 930-935.
  19. Wang, P. Y., Chen, T. L., Tsai, S. W. 2006. “Hydrolytic resolution of (R,S)-ethyl 2-chloromandelate in biphasic media via Klebsiella oxytoca hydrolase,” Enzyme and Microb. Technol., 39, 930-935.
  20. Chen, C. C., Chen, T. L., Tsai, S. W. 2006. “Altering lipase activity and enantioselectivty in organic media using organo-soluble bases: implication for rate-limiting proton transfer in acylation step,” Biotechnol. Bioeng., 94, 201-208.
  21. Cambon, E., Gouzou, F., Pina, M., Barea, B., Barouh, N., Lago, R., Ruales, J., Tsai, S. W., Villeneuve, P. 2006. “Comparison of the lipase activity in hydrolysis and acyltransfer reactions of two latex plant extracts from Babaco (Vasconcellea x Heilbornii Cv.) and Plumeria rubra: Effect of the aqueous microenvironment,” J. Agri. Food Chem., 84, 2726-2731.
  22. Ng, I. S., Tsai, S. W. 2006. “Investigation of lipases from various Carica papaya varieties for hydrolysis of olive oil and kinetic resolution of (R,S)-profen 2,2,2-trifluoroethyl thioesters,” Process Biochemistry, 41, 540-546.

研討會論文

  1. Kao, M. F., Lu, P. Y., Kao, J. Y., Wang, P. Y., Wu, A. C., Tsai, S. W., 2010. “(R,S)-2-chlorophenoxylpyrazolides as extreme substrates forimproving lipase-catalyzed hydrolytic resolution,” YABEC, Chung-Li, ROC.
  2. Wang, P. Y., Tsai, S. W., 2010. “Kinetic resolution of (R,S)-pyrazolides containing substituents in the leaving pyrazole for increased lipase enantioselectivity,” AIChE Annual Meeting, Salt Lake City, USA.
  3. Wu, A. C., Wang, P. Y., Tsai, S. W., 2010. ”Lipase-catalyzed hydrolytic resolution of pyrazole-N-carboxylate tautomers containing substituents,” APCChE-XIII, Taipei, ROC.
  4.  Wang, P. Y., Tsai, S. W. 2009. “Hydrolysis of (R,S)-3-hydroxy-3-phenylpropionates via Klebsielle oxytoca esterase: Effects of leaving alcohol, enzyme immobilization and aqueous pH,” APBio2009, Kobe, Japan.
  5. Wang, P. Y. Chen, Y. J. Wu, A. C. Lin, Y. S. Kao, M. F. Chen, Ciou, J. F. Tsai, S. W. 2009. “(R,S)-Azolides as novel substrates for lipase-catalyzed hydrolytic resolution in organic solvents,” APBio2009, Kobe, Japan.
  6. Wang, P. Y., Tsai, S. W. 2009. “Modification of enzyme surface negative charges via covalent immobilization for tailoring the activity and enantioselectivity,” Biotrans2009, Berne, Switzerland.
  7. Wang, P. Y., Tsai, S. W. 2008. “Enzymatic hydrolytic resolution of (R,S)-tropic acid esters and (R,S)-ethyl α-methoxyphenylacetate in biphasic media,” The 4th International Symposium on Biocatalysis and Biotechnology,” Taipei, ROC.
  8. Wang, P. Y., Tsai, S. W., Chen, T. L. 2008. “Improvement of enantioselectivity and stability of Klebsiella oxytoca hydrolase immobilized on Eupergit C 250L,” The 13th International Biotechnology Symposium & Exhibition, Dalian, China.
  9. Wang, P. Y., Tsai, S. W., 2008. Improvements of Enzyme Activity and Enantioselectivity via Combined Substrate Engineering and Covalent Immobilization,” Gorden Research Conference: Biocatalysis, Smithfield, RI, USA.
  10. Wang, P. Y., Chen, T. L., Tsai, S. W., 2007. “Enzymatic hydrolytic resolution of (R,S)-α-chlorophenyl acetates in biphasic media,” ApBioChEC’07, Taipei, ROC.
  11. Wang, P. Y., Chen, T. L., Tsai, S. W., Kroutil , W., 2007. “Hydrolytic Resolution of (R,S)-2-Hydroxycarboxylic Acid Esters in Biphasic Media: Implication for Rate-Limiting Formation or Breakdown of Tetrahedral Intermediates in Acylation Step,” Biotrans2007, Oviedo, Spain.
  12. Wang, P. Y., Chen, T. L., Tsai, S. W. Cipiciani, A., Bellezza, F. and Ruzziconi R. 2006. “Enantioselective hydrolysis of methyl 2-fluoro-2-arylpropionates by lipases in water-saturated isooctane,” Biocat2006, Humburg, Germany.

其他著作

  1. 蔡少徫，2005，「二十一世紀新化學工程」，第八章：生化工程簡介，周更生主編，五南圖書出版社，141-151。
  2. 徐靄可、蔡少徫，2004，利用核磁共振光譜線上分析進行反應監視及程式最佳化，化工，51(2)，83-88。
  3. 蔡少徫，2003，酵素科技在化學工業之應用，化工技術，11(5)，196-207。
  4. 徐藹可‧蔡少偉，製程開發之經濟因素考量，化工會刊，第四十九卷，第五期，第96-103頁（2002）。
  5. 蔡少徫，2002，「生物化學工程」，第五章：固定化生物觸媒，黃世佑主編，國立台灣大學生物技術研究中心出版，33-51。
  6. Yeh, H. M. and Tsai, S. W. 1986. “Separation theory in thermal diffusion columns”, in Handbook for Heat and Mass Transfer Operation, Cheremisinoff, N. P. Ed., Gulf Publishing, pp. 1265-1281. (USA)

研究

研究領域

  • 酵素應用於光學異構藥物或其中間體之製程開發（(S)-profens系列藥物、(R)-2-arylamine等）
  • 應用微生物醱酵生產酵素（lipase、creatinase等）

專利與成果

  • Tsai, S. W. 2009, “Enzymatic resolution of an alpha-substituted carboxylic acid or an ester thereof by Carica papaya lipase”, Japan Patent 4247545.
  • Tsai, S. W. and Chang C. S. 2001. “Processes for preparing optically active (S)-a-aryl propionic acid or ester thereof”, US Patent 6201151.
  • 蔡少徫、張春生，2002，光學活性S形2-芳香取代基丙酸（(S)-profens）或其S形酯類之製造方法，中華民國專利150558號。
  • 蔡少徫，2007，以木瓜脂肪分解酵素進行α-取代基酸或其酯類化合物之動力分割的方法，中華民國專利I276687號，(有效期 2007/03/21 - 2024/06/29)。

期刊編輯委員

  • Journal of Molecular Catalysis B: Enzymatic(2009- )
  • Journal of the Taiwan Institute of Chemical Engineers (JTIChE) (2009-)
  • Tamkang Journal of Science and Engineering (2004-)
  • 科學發展(Science Development, in Chinese) (2000-)
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