跳到主要內容區塊
:::

資訊分類清單

:::
  1. 首頁
  2. 總表

陳美瑾 (Mei-Chin Chen) 教授

ImgDesc

陳美瑾 (Mei-Chin Chen) 教授

聯絡方式：

研究室：93912    
分機號碼：(06)-2757575轉62696
傳真：(06)-2344496
E-mail：kokola@mail.ncku.edu.tw
研究專長：
生醫高分子、藥物控制釋放、奈米藥物載體、高分子微針貼片、經皮給藥系統

學歷

  • 國立清華大學 化工系 博士(中華民國 9309 - 9707 )
  • 國立清華大學 化工系 碩士(中華民國 9109 - 9306 )
  • 國立中央大學 化材系 學士(中華民國 8709 - 9106) 

經歷

  • 國立成功大學 教授 (1070801- now)
  • 國立成功大學 副教授 (1020801 - 1070731)
  • 國立成功大學 助理教授 (980801 - 1020731)

開授課程

  • 上學期, 化工系 藥物傳遞系統與劑型
  • 下學期, 化工系 化學反應工程
  • 下學期, 化工所 生物材料特論

教師著作

A-1. SCI Papers: the last 10 years

(表列SCI impact factor 為2020年資料)

  1. Chiu, Y.-H., Wu, Y.-W., Hung, J.-I., Chen, M.-C.*, “Epigallocatechin Gallate/L-Ascorbic Acid-Loaded Poly-g-Glutamate Microneedles with Antioxidant, Anti-inflammatory, and Immunomodulatory Effects for the Treatment of Atopic Dermatitis,” Acta Biomaterialia, 2021. (IF 8.947) on-line available
  2. Chen, Y.-W., Chen, M.-C., Wu, K.-W., Tu, T.-Y.*, “A Facile Approach for Rapid Prototyping of Microneedle Molds, Microwells and Micro-through-Holes in Various Substrate Materials using CO2 Laser Drilling,” Biomedicines, vol. 8, 427, 2020. (IF 6.081)
  3. Chen, M.-C.*, Chen, C.-S., Wu, Y.-W., Yang, Y.-Y., “Poly-γ-Glutamate Microneedles as Transdermal Immunomodulators for Ameliorating Atopic Dermatitis-Like Skin Lesions in Nc/Nga Mice,” Acta Biomaterialia, vol. 114, pp. 183-192, 2020. (IF 8.947)
  4. Wu, Y.-W., Chen, M.-C., Chen, Y.-H.*, “Potential Zika Vaccine: Encapsulated Nanocomplex Promotes Both TH1/TH2 Responses in Mice,” Advanced Therapeutics, vol. 3, 1900197, 2020.
  5. Chen, Y.-H., Lai, K.-Y., Wu, Y.-W., Chiu, Y.-H., Shiau, A.-L., Chen, M.-C.*, “Implantable Microneedles with an Immune-Boosting Function for Effective Intradermal Influenza Vaccination,” Acta Biomaterialia, vol. 97, pp. 230-238, 2019. (IF 8.947)
  6. Chiu, Y.-H., Chen, M.-C.*, Wan, S.-W., “Sodium Hyaluronate/Chitosan Composite Microneedles as a Single-Dose Intradermal Immunization System,” Biomacromolecules, vol. 19, pp. 2278-2285, 2018. (IF 6.988)
  7. Chen, M.-C.*, Lai, K.-Y., Ling, M.-H., Lin, C.-W., “Enhancing Immunogenicity of Antigens through Sustained Intradermal Delivery using Chitosan Microneedles with a Patch-Dissolvable Design,” Acta Biomaterialia, vol. 65, pp. 66-75, 2018. (IF 8.947)
  8. Chen, M.-Y., Chen, Y.-Y., Tsai, H.-T., Tsai, T.-S., Chen, M.-C.*, Tsai, Y-S.*, “Transdermal Delivery of Luteinizing Hormone-Releasing Hormone with Chitosan Microneedles: a Promising Tool for Androgen Deprivation Therapy,” Anticancer Research, vol. 37, pp. 6791-6797, 2017. (IF 2.480)
  9. Su, L.-C., Chen, M.-C.*, “Efficient Delivery of Nanoparticles to Deep Skin Layers using Dissolvable Microneedles with an Extended-Length Design,” Journal of Materials Chemistry B, vol. 5, pp. 3355-3363, 2017. (IF 6.331)
  10. Hsueh, K.-J., Chen, M.-C., Cheng, L.-T., Lee, J.-W., Chung, W.-B., Chu, C.-Y.*, “Transcutaneous Immunization of Streptococcus suis Bacterin using Dissolving Microneedles,” Comparative Immunology, Microbiology and Infectious Diseases, vol. 50, pp. 78-87, 2017. (IF 2.268)
  11. Chen, M.-C.*, Chan, H.-A., Ling, M.-H., Su, L.-C., “Implantable Polymeric Microneedles with a Phototriggerable Property as a Patient-Controlled Transdermal Analgesia System,” Journal of Materials Chemistry B, vol. 5, pp. 496-503, 2017. (IF 6.331)
  12. Chen, M.-C.*, Lin, Z.-W., Ling, M.-H., “Near-Infrared Light-Activatable Microneedle System for Treating Superficial Tumors by Combination of Chemotherapy and Photothermal Therapy,” ACS Nano, vol. 10, pp. 93-101, 2016. (IF 15.881)
  13. Chen, M.-C.*, Ling, M.-H., Kusuma, S.-J., “Poly-g-glutamic Acid Microneedles with a Supporting Structure Design as a Potential Tool for Transdermal Delivery of Insulin,” Acta Biomaterialia, vol. 24, pp. 106-116, 2015. (IF 8.947)
  14. Chen, M.-C.*, Ling, M.-H., Wang, K.-W., Lin, Z.-W., Lai, B.-H., Chen, D.-H.*, “Near-Infrared Light-Responsive Composite Microneedles for On-demand Transdermal Drug Delivery,” Biomacromolecules, vol. 16, pp. 1598-1607, 2015. (IF 6.988)  
  15. Ko, P.-T., Lee, I.-C., Chen, M.-C., Tsai, S.-W.*, “Polymer Microneedles Fabricated from PCL and PCL/PEG Blends for Transdermal Delivery of Hydrophilic Compounds,” Journal of the Taiwan Institute of Chemical Engineers, vol. 51, pp. 1-8, 2015. (IF 5.876)
  16. Chen, M.-C.*, Wang, K.-W., Chen, D.-H., Ling, M.-H., Liu, C.-Y., “Remotely Triggered Release of Small Molecules from LaB6@SiO2-loaded Polycaprolactone Microneedles,” Acta Biomaterialia, vol. 13, pp. 344-353, 2015. (IF 8.947)
  17. Su, L.-C., Chen, Y.-H.*, Chen, M.-C.*, “Dual Drug-eluting Stents Coated with Multi-layers of Hydrophobic Heparin and Sirolimus,” ACS Applied Materials & Interfaces, vol. 5, pp. 12944-12953, 2013. (IF 9.229)
  18. Ling, M.-H., Chen, M.-C.*, “Dissolving Polymer Microneedle Patches for Rapid and Efficient Transdermal Delivery of Insulin to Diabetic Rats,” Acta Biomaterialia, vol. 9, pp. 8952-8961, 2013. (IF 8.947) 
  19. Chen, M.-C.*, Huang, S.-F., Lai, K.-Y., Ling, M.-H., “Fully Embeddable Chitosan Microneedles as a Sustained Release Depot for Intradermal Vaccination,” Biomaterials, vol. 34, pp.3077-3086, 2013. (IF 12.479)
  20. Chen, M.-C.*, Sun, Y.-C., Chen, Y.-H., “Electrically Conductive Nanofibers with Highly Oriented Structures and their Potential Application in Skeletal Muscle Tissue Engineering,” Acta Biomaterialia, vol. 9, pp.5562-5572, 2013. (IF 8.947)
  21. Chen, M.-C., Mi, F.-L., Liao, Z.-X., Hsiao, C.-W., Sonaje, K., Chung, M.-F., Hsu, L.-W., Sung, H.-W.*, “Recent Advances in Chitosan-based Nanoparticles for Oral Delivery of Macromolecules,” Advanced Drug Delivery Reviews, vol. 65, pp.865-879, 2013. (IF 15.470)
  22. Chen, M.-C.*, Ling, M.-H., Lai, K.-Y., Pramudityo, E., “Chitosan Microneedle Patches for Sustained Transdermal Delivery of Macromolecules,” Biomacromolecules, vol. 13, pp.4022-4031, 2012. (IF 6.988)
  23. Chen, M.-C., Sonaje, K., Chen, K.-J., Sung, H.-W.*, “A Review of the Prospects for Polymeric Nanoparticle Platforms in Oral Insulin Delivery,” Biomaterials, vol. 32, pp.9826-9838, 2011. (IF 12.479)
  24. Chen, M.-C., Mi, F.-L., Liao, Z.-X., Sung, H.-W.*, “Chitosan: Its Applications in Drug Eluting Devices,” Advances in Polymer Science, vol. 243, pp.185-230, 2011. (IF 6.802)
  25. Lee, W.-Y., Cheng, W.-Y., Yeh, Y.-C., Lai, C.-H., Hwang, S.-M., Hsiao, C.-W., Chen, M.-C.*, Sung, H.-W.*, “Magnetically-directed Self-assembly of Electrospun Superparamagnetic Fibrous Bundles to Form Three-dimensional Tissues with a Highly Ordered Architecture,” Tissue Engineering: Part C, vol. 17, pp.651-661, 2011. (IF 3.056)

A-2. 技術期刊

  1. 邱鈺琇, 陳美瑾*, “經皮免疫新策略：可無痛標的傳輸疫苗之高分子微針貼片,” 化工, 第62卷, pp. 71-83, 2015.
  2. 蘇良晟, 陳美瑾*, “心血管支架之發展與未來展望,” 化工月刊, 2014年8月號, pp. 56-80, 2014.
  3. 蘇良晟, 陳美瑾*, “具抗凝血與抗血管內膜增生之雙效型藥物釋放血管支架,”界面科學會誌, 第32卷, pp.10-18, 2010.
  4. 陳美瑾*, “大分子藥物之經皮傳輸新利器—無痛式高分子微針貼片,” 化學, 第68卷第3期, pp.215-223, 2010.

A-3. 專書

  1. 何國淵, 陳美瑾*, “智慧藥物傳遞系統‒高分子微針貼片,” 創新醫療器材應用與實作, pp. 136-152, 2019.

B. Conference Papers: the last 3 years

    1. Chang, C.-C. (張芷綺), Chen, Y.-L., Chen, M.-C.*, “Curcumin-loaded PLGA/HA microneedles with anti-oxidant, anti-inflammation, and moisturizing effect for treatment of atopic dermatitis”, 2020 International Symposium on Novel and Sustainable Technology, 2020. 獲得Excellent Oral Presentation Award. (2020/11/27)  
    2. Chen, Y.-L. (陳羿綸), Yang, Y.-Y., Chen, M.-C.*, “Tacrolimus-loaded γ-PGA/PLGA Microneedles for Ameliorating Atopic Dermatitis Symptoms in Nc/Nga Mice”, 2020台灣化學工程學會67週年年會暨科技部化工學門成果發表會&台日韓捷永續化學工程國際研討會，獲得壁報競賽優勝。(2020/10/23~10/24)
    3. Yang, Y.-Y. (楊茵茵), Chen, M.-C.*, “Implantable Tacrolimus-loaded Gamma-PGA/PLGA Double-layered Microneedles for Attenuating Atopic Dermatitis Symptoms in Nc/Nga Mice”, 2019 International Symposium on Novel and Sustainable Technology, 2019. 獲得Excellent Award of Oral Presentation Student. (12/12)
    4. Chen, Y.-L. (陳羿綸), Chang, C.-C., Chen, M.-C.*, “Sustained Release of Molsidomine Using Embeddable PLGA-PVP/PVA Core-Shell Microneedles for Primary Osteoporosis Treatment”, 2019 International Symposium on Novel and Sustainable Technology, 2019. 獲得First Prize of Poster Presentation Student. (12/12)
    5. Lin, Z.-Y. (林姿瑜), Chuang, M.-C., Chen, M.-C.*, “Synergistic Effect of Poly-Gamma-Glutamate Microneedles and Chitosan/Hyaluronic Acid Nanoparticles on Transcutaneous Immunization”, 2019 International Symposium on Novel and Sustainable Technology, 2019. 獲得Excellent Award of Poster Presentation Student.
    6. Chen, Y.-L., Chang, C.-C., Chen, M.-C.*, “Sustained Release of Molsidomine Using Embeddable PLGA Microneedles for Primary Osteoporosis Treatment” FAPS 2019 Polymer Congress, 2019. 獲得Sliver Award. (10/27~10/30)
    7. Chang, C.-C., Chen, M.-C.*, “Sustained transdermal delivery of NO donor using embeddable PLGA-PVP/PVA core-shell microneedles for primary osteoporosis treatment” 2019年功能性材料研討會暨科技部專題研究計畫成果發表會，獲得海報競賽第三名。(2019/6/14) 
    8. Chuang, M.-C., Chen, M.-C.*,“Synergistic Effect of Chitosan/Hyaluronic Acid Nanoparticles and Poly-γ-Glutamic Acid Microneedles on Transcutaneous Immunization” 2019年功能性材料研討會暨科技部專題研究計畫成果發表會，獲得海報競賽第一名。(2019/06/14) 
    9. Liu, T.-T., Chen, M.-C.*, “Sustained estrogen delivery using embeddable PLGA microneedles for contraception” 2019年功能性材料研討會暨科技部專題研究計畫成果發表會，獲得海報競賽第一名。(2019/06/19)
    10. Chang, C.-C., Chen, M.-C.*, “Sustained transdermal delivery of NO donor using embeddable PLGA microneedles for primary osteoporosis treatment,” 2019國際創新藥物制放研討會暨中華民國生醫材料及藥物制放學會會，獲得壁報競賽優勝獎。(2019/3/29) 
    11. Chuang, M.-C., Chen, M.-C.*, “Encapsulation of chitosan/hyaluronic acid nanoparticles containing antigens to poly-gamma-glutamic acid microneedles for transcutaneous immunization” 2019國際創新藥物制放研討會暨中華民國生醫材料及藥物制放學會年會，獲得海報競賽特優獎。(2019/03/29)
    12. Chang, C.-C., Chen, M.-C.*, “Embeddable drug-loaded PLGA microneedles with core-shell structure for primary osteoporosis treatment,” 2019 中華民國高分子年會及前瞻高分子科學與技術國際研討會暨107年度科技部高分子學門成果發表會，獲得海報發表競賽佳作。(2019/1/18) 
    13. Chen, M.-C.*, “Near-Infrared Light-Activatable Microneedle System for Treating Superficial Tumors by Combination of Chemotherapy and Photothermal Therapy,” 2018海峽兩岸高分子學術研討會, 2018. (10/17-21，四川) Invited Lecture
    14. Chuang, M.-C., Chen, S.-Y., Chen, M.-C.*, “Potential of Chitosan/poly-gamma-glutamic acid nanoparticles as nanocarriers for vaccine delivery,” 2018 創新與永續科技國際研討會，獲得英文口頭競賽Excellent Award。(2018/10/15)
    15. Chiu, Y.-H., Chen, M.-C.*, “Chitosan microneedles with dissolvable tips as a single-dose antigen delivery system,” The 10th International Conference of Modification, Degradation and Stabilization of Polymers (MoDeSt 2018). (9/2~9/6)
    16. Chen, S.-Y., Chen, M.-C.*, “Effect of surface charges of chitosan/poly-gamma-glutamic acid nanocomplex on transdermal immunization,” 2018中華民國界面科學學會年會，獲得口頭報告競賽優勝獎。(2018/8/10) 
    17. 何國淵、陳美瑾*, “包覆NO DONOR之PLGA微粒應用於原發性骨質疏鬆症之治療,” 2018中華民國界面科學學會年會，獲得口頭報告競賽佳作獎。(2018/8/10) 
    18. 邱鈺琇、陳美瑾*, “可兩階段式經皮釋放抗原之透明質酸鈉/幾丁聚醣複合式疫苗微針,” 2018生醫材料及藥物制放學會暨研討會，獲得壁報論文競賽第三名。(2018/3/23)
    19. Chen, S.-Y., Yang, H.-K., Chen, M.-C.*, “Transdermal Delivery of Alendronate-loaded PLGA Microparticles using Hyaluronic Acid Microneedles for the Treatment of Osteoporosis,” 2018中華民國高分子學會年會，獲得壁報競賽金牌獎。(2018/1/13)
    20. Chiu, Y.-H., Chen, M.-C.*, “Enhancement of Antigen-Specific Immune Responses through Prime-Boost Vaccination Strategies using Hyaluronic Acid/Chitosan Microneedles,” 2018中華民國高分子學會年會，獲得壁報競賽銅牌獎。(2018/1/13)

C. Patents

  1. Sung, H.-W., Chen, M.-C., Tu, P., and Tu, H., “Drug-eluting Stent having Collagen Drug Carrier Chemically Treated with Genipin,” U.S. Patent No. 7,351,421, 4/1/2008.
  2. Sung, H.-W., Chen, M.-C., Lee, P.-W., and Tu, H., “Nanoparticles for Protein/Peptide Delivery and Delivery Means,” U.S. Patent No. 7,449,200, 11/11/2008.
  3. Sung, H.-W., Chen, M.-C., Lin, Y.-H., Tu, H., “Nanoparticles for Protein Drug Delivery,” U.S. Patent No. 7,541,046 B1, 6/2/2009.
  4. Sung, H.-W., Lin, Y.-H., Chen, M.-C., and Tu, H., “Nanoparticles for Monoclonal Antibody Delivery,” U.S. Patent No. 7,541,028 B2, 6/2/2009.
  5. Sung, H.-W., Chen, M.-C., Lin, Y.-H., Liang, H.-F., and Tu, H., “Nanoparticles for Protein Drug Delivery,” U.S. Patent No. 7,858,596 B2, 12/28/2010.
  6. Sung, H.-W., Lin, Y.-H., Chen, M.-C., and Tu, H., “Nanoparticles for Drug Delivery,” U.S. Patent No. 7,879,361 B2, 2/1/2011.
  7. Sung, H.-W., Chen, M.-C., Lee, P.-W., Tu, H., “Nanoparticles for Protein/Peptide Delivery and Delivery Means Thereof,” U.S. Patent No. 7,901,711 B1, 3/8/2011.
  8. Sung, H.-W., Chen, M.-C., Lin, Y.-H., Liang, H.-F., and Tu, H., “Nanoparticles for Protein Drug Delivery,” U.S. Patent No. 7,919,293 B2, 4/5/2011.
  9. Sung, H.-W., Chen, M.-C., Tu, H., “Nanoparticles for targeting hematoma cells and delivery means,” U.S. Patent No. 7,985,426 B1, 7/26/2011.
  10. Sung, H.-W., Chen, M.-C., Lee, P.-W., Tu, H., “Nanoparticles for Protein/Peptide Delivery and Delivery Means Thereof,” U.S. Patent No. 8,137,697 B1, 3/20/2012.
  11. Chen, M.-C., Chen, D.-H., Wang, K.-W., Lai, B.-H., “Transdermal Drug Delivery Patch and Method of Controlling Drug Release of the Same by Near-IR,” U.S. Patent No. 8,834,447 B2, 9/16/2014.
  12. Chen, M.-C., Huang, S.-F., “Embeddable Microneedle Patch for Transdermal Drug Delivery and Method of Manufacturing the Same,” U.S. Patent No. US 9,675,789 B2, 6/13/2017.
  13. Chen, M.-C., Lai, K.-Y., Lin, C.-W., Ling, M.-H., “Substance Delivery Device and Substance Delivery Method using the Same,” U.S. Patent No. US 10,028,905 B2, 7/24/2018. (專利期限03/11/2035)
  14. Chen, M.-C., Lin, Z.-Y., Chen, C.-S., “Substance Delivery Device and Substance Delivery Method using the Same,” US 10,869,832 B2, 12/22/2020.  (專利期限03/11/2035)
  15. 陳美瑾、陳東煌、王冠雯、賴柏宏，“經皮藥物釋放貼片及利用近紅外光控制其藥物釋放之方法”中華民國專利證書號數TW I458504 B，公告日11/1/2014。
  16. 陳美瑾、賴冠穎、林駿崴、凌銘鴻，“微針經皮傳輸裝置及應用其之微針經皮傳輸方法”中華民國專利證書發明第I528975號，專利權期間自2016年4月11日至2033年7月11日止。
  17. 陳美瑾、黃詩方，“鑲嵌式經皮藥物釋放貼片及其製造方法”中華民國專利證書發明第I554289號，專利權期間自2016年10月21日至2032年6月28日止。
  18. 朱純燕、陳美瑾、薛凱仁，“微針貼片型豬用疫苗” 中華民國專利證書發明第I564035號，專利權期間自2017年1月1日至2035年5月3日止。
  19. Sung, H.-W, Chen, M.-C., Tu, P., and Tu, H., “Drug-Eluting Biodegradable Stent“ 美國專利 (USPTO 10/916,170, filed on 8/11/2004)
  20. Sung, H.-W., Chen, M.-C., and Tu, H., “Delivery Means for Drug-eluting Biodegradable Stent,” 美國專利 (USPTO 11/048,589, filed on 2/1/2005).
  21. Sung, H.-W., Chen, M.-C., and Tu, H., “Drug-eluting Biodegradable Stent,” 美國專利 (USPTO 11/130,787, filed on 5/17/2005).
  22. Sung, H.-W., Chen, M.-C., and Tu, H., “Biodegradable Occlusive Device with Moisture Memory,” 美國專利(USPTO 11/180,498, filed on 7/12/2005).
  23. Sung, H.-W., Chen, M.-C., and Tu, H., “Medical Device with Living Cell Sheet,” 美國專利 (USPTO 11/412,610, filed on 4/27/2006).
  24. Sung, H.-W., Lin, Y.-H., Chen, M.-C., Tu, H., “Nanoparticles for Drug Delivery,” 美國專利 (USPTO 12/008,556, filed on 1/11/2007)

研究

 學術榮譽

  1. 2011年6月獲選為「成功大學工學院明日之星」
  2. 2013年12月獲得臺灣綜合大學系統「年輕學者創新研究選拔」之傑出獎
  3. 2015年5月獲得104年度李昭仁教授基金會生醫工程「年輕學者獎」
  4. 2015年5月獲得Best Young Investigator Oral Presentation Award in the 5th Asian Biomaterials Congress
  5. 2015年11月參加科技部工程司104年度先導開發型產學合作計劃化材民生領域成果發表暨績效考評會議榮獲海報展示傑出獎。
  6. 2016年3月參加『李昭仁教授紀念研討會』年輕學者組口頭論文競賽優等。
  7. 2016年7月獲得104學年度成功大學化工系教學優良教師
  8. 2016年9月獲得105年度中國工程師學會『工程論文獎』。
  9. 2016年11月獲得化工學會105年度『化工傑作獎』及『傑出論文獎』。
  10. 2017年3月獲頒成功大學105年度產學合作成果特優教師『優良獎』。
  11. 2017年11月獲得化工學會106年度『學術勵進獎』。
  12. 2017年11月獲得科技部106年度『吳大猷先生紀念獎』。
  13. 2018年3月獲頒106年度產學合作成果特優教師『特優獎』。
  14. 2018年10月參加科技部工程司107年度產學合作計畫成果發表暨績效考評會榮獲海報展示特優獎。
  15. 2018年12月獲得『107年度國立成功大學工學院學術優良教師』。
  16. 2019年11月榮膺108學年度『李國鼎研究獎』。
  17. 2020年4月獲得108學年度成功大學化工系教學優良教師。
  18. 2020年8月獲得李昭仁教授基金會『研究學者獎』。
  19. 2021年5月榮獲110年度中國工程師學會高雄分會之『工程教授獎』。

 指導學生參與非研討會競賽得獎

  1. 專題生-周宛璇獲得「科技部100年度大專生研究計劃研究創作獎」
  2. 專題生-陳玟璇獲得「科技部103年度大專生研究計劃研究創作獎」(104/8/5)
  3. 研究生-陳怡穎獲得「2016中華民國生物醫學工程創意競賽佳作」(105/8/17)
  4. 專題生-汪維萱獲得「中國工程師學會學生分會106年度工程論文競賽佳作獎」(106/5/27)
  5. 專題生-林姿瑜獲得「科技部108年度大專生研究計劃研究創作獎」(109/7/15)
  6. 專題生-張芷綺獲得「科技部109年度大專生研究計劃研究創作獎」(110/7/01)

服務

  • 99學年學生事務委員會召集人
  • 100學年經費委員會召集人
  • 101學年學生事務委員會召集人
瀏覽數:
加到我的最愛